Anti-MYSM1 antibody
Specifications
| Product Cat#: | AB-07-0857 |
| Immunogen: | A synthetic peptide derived from human MYSM1. The exact amino-acid sequence is proprietary. |
| Antigen: | MYSM1 |
| Product type: | Primary antibody |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:40000); Immunohistochemistry (1:50~1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Myb-like; SWIRM and MPN domain-containing protein 1 |
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Target information
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis and lymphocyte differentiation (PubMed:28115216, PubMed:26220525).
Provider
Erpantech Laboratory
