Anti-MyD88 antibody
Specifications
| Product Cat#: | AB-06-3017 |
| Product type: | Primary antibody |
| Antigen: | MyD88 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:100-1:500); Immunofluorescence |
| Clonality (clone number): | Monoclonal (SC65-04) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | Mutant myeloid differentiation primary response 88 antibody |
| MYD 88 antibody | |
| Myd88 antibody | |
| MYD88_HUMAN antibody | |
| MYD88D antibody | |
| Myeloid differentiation marker 88 antibody | |
| Myeloid differentiation primary response 88 antibody | |
| Myeloid differentiation primary response gene (88) antibody | |
| Myeloid differentiation primary response gene 88 antibody | |
| Myeloid differentiation primary response gene antibody | |
| Myeloid differentiation primary response protein MyD88 antibody | |
| OTTHUMP00000161718 antibody | |
| OTTHUMP00000208595 antibody | |
| OTTHUMP00000209058 antibody | |
| OTTHUMP00000209059 antibody | |
| OTTHUMP00000209060 antibody |
Target information
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Provider
Erpantech Laboratory