Anti-MUL1 antibody
Specifications
| Product Cat#: | AB-06-3003 |
| Product type: | Primary antibody |
| Antigen: | MUL1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human MUL1/RNF218 1-100/352 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800); Immunofluorescence (1:50-1:200); Flow Cytometry (1ug/test); Immunocytochemistry |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | E3 ubiquitin-protein ligase MUL1 |
| C1orf166 | |
| E3 ubiquitin ligase | |
| E3 ubiquitin protein ligase MUL1 | |
| GIDE | |
| Growth inhibition and death E3 ligase | |
| MAPL | |
| Mitochondrial anchored protein ligase | |
| Mitochondrial ubiquitin ligase activator of NFKB 1 | |
| MUL1 | |
| MULAN | |
| Putative NF kappa B activating protein 266 | |
| RING finger protein 218 | |
| RNF218 | |
| RP23-25C1.10-002 |
Target information
Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at ‘Lys-284’ involving ‘Lys-48’-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).
Provider
Erpantech Laboratory
