Anti-MOB1A antibody
Specifications
| Product Cat#: | AB-06-2926 |
| Product type: | Primary antibody |
| Antigen: | MOB1A |
| Immunogen: | Purified recombinant fragment of human MOB1A expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (B2-E7) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | MATS 2 antibody |
| MATS2 antibody | |
| MGC33910 antibody | |
| Mob 1A antibody | |
| Mob 1B antibody | |
| MOB 4A antibody | |
| MOB kinase activator 1B antibody | |
| Mob1 homolog 1A antibody | |
| MOB1 Mps One Binder homolog B antibody | |
| MOB1 Mps one binder kinase activator like 1A antibody | |
| Mob1A antibody | |
| Mob1B antibody | |
| MOBKL 1A antibody | |
| MOBKL1A antibody | |
| MOL1A_HUMAN antibody | |
| Mps one binder kinase activator like 1A antibody | |
| Mps one binder kinase activator-like 1A antibody | |
| Protein Mob4A antibody |
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Target information
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Provider
Erpantech Laboratory