Anti-MELK antibody
Specifications
| Product Cat#: | AB-06-2862 |
| Product type: | Primary antibody |
| Antigen: | MELK |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Immunohistochemistry (1:200-1:1000); Flow Cytometry (1:100-1:200); Immunocytochemistry (1:200-1:1000); ELISA |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (B7-G2) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | AI327312 antibody |
| HMELK antibody | |
| HPK 38 antibody | |
| HPK38 antibody | |
| KIAA0175 antibody | |
| Likely ortholog of maternal embryonic leucine zipper kinase antibody | |
| Maternal embryonic leucine zipper kinase antibody | |
| MELK antibody | |
| MELK_HUMAN antibody | |
| MKIAA0175 antibody | |
| MPK38 antibody | |
| OTTHUMP00000021377 antibody | |
| OTTHUMP00000046113 antibody | |
| PEg3 kinase antibody | |
| Protein kinase Eg3 antibody | |
| Protein kinase PK38 antibody | |
| RP23 382O11.1 antibody | |
| Tyrosine protein kinase MELK antibody |
Target information
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Provider
Erpantech Laboratory
