Anti-MDM2 antibody
Specifications
| Product Cat#: | AB-06-2839 |
| Product type: | Primary antibody |
| Antigen: | MDM2 |
| Immunogen: | Amino acids 154-167 of MDM2 of human origin |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:100-1:1000); Immunoprecipitation(1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunohistochemistry (1:50-1:500); Immunofluorescence(1:50-1:500); Immunohistochemistry-Paraffin |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (3G2) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | ACTFS antibody |
| Double minute 2 protein antibody | |
| E3 ubiquitin-protein ligase Mdm2 antibody | |
| Hdm 2 antibody | |
| Hdm2 antibody | |
| HDMX antibody | |
| MDM 2 antibody | |
| MDM2 antibody | |
| MDM2 oncogene E3 ubiquitin protein ligase antibody | |
| Mdm2 p53 E3 ubiquitin protein ligase homolog antibody | |
| Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody | |
| MDM2_HUMAN antibody | |
| MDM2BP antibody | |
| Mouse Double Minute 2 antibody | |
| MTBP antibody | |
| Murine Double Minute Chromosome 2 antibody | |
| Oncoprotein Mdm2 antibody | |
| P53 Binding Protein Mdm2 antibody | |
| P53-binding protein Mdm2 antibody | |
| Ubiquitin protein ligase E3 Mdm2 antibody |
Target information
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).
Provider
Erpantech Laboratory