Anti-MASH1 antibody
Specifications
| Product Cat#: | AB-06-2808 |
| Product type: | Primary antibody |
| Antigen: | MASH1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human ASCL1 151-250/236 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Cow, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | Achaete scute complex homolog 1 |
| ASCL1 | |
| MASH1/Achaete-scute homolog 1 | |
| Achaete scute complex homolog like 1 | |
| Achaete scute complex homologue 1 | |
| Achaete scute complex homologue like 1 | |
| Ascl 1 | |
| Ascl1 | |
| Ash 1 | |
| Ash1 | |
| Hash 1 | |
| Hash1 | |
| Mammalian achaete scute homolog 1 | |
| Mammalian achaete scute homologue 1 | |
| Mash 1 | |
| Mash1 | |
| Achaete-scute homolog 1 | |
| ASCL1_HUMAN | |
| ASH-1 | |
| hASH1 | |
| Class A basic helix-loop-helix protein 46 |
Target information
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5′-CANNTG-3′) on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation.
Provider
Erpantech Laboratory
