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Anti-MARK2 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-2804
Anti-MARK2 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-2804
Product type: Primary antibody
Antigen: MARK2
Immunogen: Recombinant protein near the C-terminus of human MARK2.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot(1:500-1:2000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:100-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal (JE40-97)
Form: Liquid
Buffer: TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles
Alternative names: ELKL motif kinase 1 antibody
ELKL motif kinase antibody
EMK-1 antibody
EMK1 antibody
MAP/microtubule affinity regulating kinase 2 antibody
MAP/microtubule affinity-regulating kinase 2 antibody
Mark2 antibody
MARK2_HUMAN antibody
MGC99619 antibody
PAR 1 antibody
Par 1b antibody
PAR1 homolog antibody
Par1b antibody
Ser/Thr protein kinase PAR 1B antibody
Serine/threonine protein kinase EMK antibody
Serine/threonine protein kinase MARK2 antibody
Serine/threonine-protein kinase MARK2 antibody
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Target information

Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

Provider

Erpantech Laboratory

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MSDS-AB-06-2804.pdf (192 downloads )