Anti-Mad2L2 antibody
Specifications
| Product Cat#: | AB-06-2773 |
| Product type: | Primary antibody |
| Antigen: | Mad2L2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunoprecipitation(1:10-1:50); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JU99-23) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Homolog of REV7 S cerevisiae antibody |
| hREV7 antibody | |
| MAD2 (mitotic arrest deficient yeast, homolog) like 2 antibody | |
| MAD2 homolog antibody | |
| MAD2 like 2 antibody | |
| MAD2 mitotic arrest deficient like 2 antibody | |
| MAD2-like protein 2 antibody | |
| MAD2B antibody | |
| Mad2l2 antibody | |
| MD2L2_HUMAN antibody | |
| Mitotic Arrest Deficient 2 L2 antibody | |
| Mitotic arrest deficient 2-like protein 2 antibody | |
| Mitotic arrest deficient homolog like 2 antibody | |
| Mitotic arrest deficient like 2 (yeast) antibody | |
| Mitotic arrest deficient yeast homolog antibody | |
| Mitotic spindle assembly checkpoint protein MAD2B antibody | |
| Polymerase (DNA directed) zeta 2 accessory subunit antibody | |
| POLZ2 antibody | |
| REV 7 antibody | |
| REV7 antibody | |
| REV7 homolog antibody | |
| Weakly similar to Mitotic MAD2 protein (S cerevisiae) antibody |
Target information
Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).
Provider
Erpantech Laboratory
