Anti-LRRK1 antibody
Specifications
| Product Cat#: | AB-06-2742 |
| Product type: | Primary antibody |
| Antigen: | LRRK1 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG2b |
| Applications: | Western Blot (1:500); Immunocytochemistry (1:50-1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclona (5B1) |
| Buffer: | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | KIAA1790 antibody |
| Leucine rich repeat serine/threonine protein kinase 1 antibody | |
| Leucine-rich repeat serine/threonine-protein kinase 1 antibody | |
| LRRK 1 antibody | |
| Lrrk1 antibody | |
| LRRK1_HUMAN antibody | |
| RIPK6 antibody |
Target information
Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene. Formation of LRRK1:EGF-R complexes result in LRRK cellular translocation: LRRK1 traffics together with EGF-R to endosomes upon stimulation of the receptor with EGF. LRRK1 is related to the familial Parkinsonism gene product Park8/LRRK2, and contains a Ras of complex proteins (ROC) GTPase domain and a MAPKKK-like kinase domain. LRRK1 participates in the intercellular trafficking of the epidermal growth factor (EGF) receptor. LRRK1 is activated by the sequential phosphorylation of 2 mitotic kinases, PLK1 and CDK1. Importantly, this PLK1-dependent activation of LRRK1 is required for the regulation of mitotic spindle orientation.LRRK1 regulates spindle orientation in a manner dependent on its kinase activity. Furthermore, the spindle misorientation caused by PLK1 inactivation is rescued by expression of the phospho-mimicking mutant LRRK1(S1790D). LRRK1 regulates spindle orientation downstream of PLK1.
Provider
Erpantech Laboratory
