Anti-LRRC25 antibody
Specifications
| Product Cat#: | AB-06-2740 |
| Product type: | Primary antibody |
| Antigen: | LRRC25 |
| Immunogen: | KLH conjugated synthetic peptide derived from human LRRC25 81-180/305 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | FLJ38116 |
| Leucine rich repeat containing 25 | |
| Leucine rich repeat containing protein 25 | |
| LRRC 25 | |
| MAPA | |
| Monocyte and plasmacytoid activated molecule |
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Target information
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
Provider
Erpantech Laboratory
