Anti-LEF1 antibody
Specifications
| Product Cat#: | AB-06-2684 |
| Product type: | Primary antibody |
| Antigen: | LEF1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (B11-A4) |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | DKFZp586H0919 antibody |
| FLJ46390 antibody | |
| LEF 1 antibody | |
| LEF-1 antibody | |
| Lef1 antibody | |
| LEF1_HUMAN antibody | |
| Lymphoid enhancer binding factor 1 antibody | |
| Lymphoid enhancer-binding factor 1 antibody | |
| T cell specific transcription factor 1 alpha antibody | |
| T cell-specific transcription factor 1-alpha antibody | |
| TCF 1 alpha antibody | |
| TCF1 alpha antibody | |
| TCF1-alpha antibody | |
| TCF10 antibody | |
| TCF1alpha antibody | |
| TCF7L3 antibody | |
| Transcription factor T cell specific 1 alpha antibody |
Target information
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Provider
Erpantech Laboratory
