Anti-LC3A antibody
Specifications
| Product Cat#: | AB-08-0121 |
| Product type: | Primary antibody |
| Antigen: | LC3A |
| Immunogen: | A synthesized peptide derived from human LC3A. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-200); Immunoprecipitation (1:100-1:200) |
| Reactivity: | Human, Rat, Mouse |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 50% Glycerol, 0.02% NaN3. |
| Purity: | Protein A affinity purification. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3 |
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Target information
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141).
While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).
Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
Provider
Erpantech Laboratory