Anti-KMT3C antibody
Specifications
| Product Cat#: | AB-06-2634 |
| Product type: | Primary antibody |
| Antigen: | KMT3C |
| Immunogen: | KLH conjugated synthetic peptide derived from human KMT3C 351-433/433 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Histone Methyltransferase SMYD2 |
| HSKM B | |
| HSKM-B | |
| HSKMB | |
| KMT3C | |
| Lysine N-Methyltransferase 3C | |
| MGC119305 | |
| N lysine Methyltransferase SMYD2 | |
| N-lysine Methyltransferase SMYD2 | |
| SET and MYND Domain Containing 2 | |
| SET and MYND Domain Containing protein 2 | |
| SET and MYND Domain-Containing protein 2 | |
| Smyd2 | |
| SMYD2_HUMAN | |
| Zinc finger MYND Domain Containing 14 |
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Target information
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 ‘Lys-4’ (H3K4me) and dimethylates histone H3 ‘Lys-36’ (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates ‘Lys-370’ of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at ‘Lys-860’.
Provider
Erpantech Laboratory