Anti-KDM5B antibody
Specifications
| Product Cat#: | AB-06-2574 |
| Product type: | Primary antibody |
| Antigen: | KDM5B |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:100-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Cancer/Testis Antigen 31 antibody |
| CT31 antibody | |
| Histone Demethylase JARID1B antibody | |
| JARID1B antibody | |
| Jumonji AT Rich Interactive Domain 1B antibody | |
| Jumonji/ARID Domain-Containing Protein 1B antibody | |
| Kdm5b antibody | |
| KDM5B_HUMAN antibody | |
| Lysine (K) Specific Demethylase 5B antibody | |
| Lysine Demethylase 5B antibody | |
| Lysine Specific Demethylase 5B antibody | |
| Lysine-Specific Demethylase 5B antibody | |
| PLU-1 antibody | |
| PLU1 antibody | |
| PPP1R98 antibody | |
| Protein Phosphatase 1 Regulatory Subunit 98 antibody | |
| PUT1 antibody | |
| Putative DNA/Chromatin Binding Motif antibody | |
| RBBP2H1A antibody | |
| RBP2 like antibody | |
| RBP2-H1 antibody | |
| Retinoblastoma-Binding Protein 2 Homolog 1 antibody | |
| Retinoblastoma-Binding Protein 2 Homolog 1A antibody |
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Target information
Histone demethylase that demethylates ‘Lys-4’ of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 ‘Lys-9’ or H3 ‘Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ‘Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Provider
Erpantech Laboratory
