Anti-KAT2A antibody
Specifications
| Product Cat#: | AB-06-4854 |
| Product type: | Primary antibody |
| Antigen: | KAT2A |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human KAT2A. AA range: 691-740. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:50-200) |
| Reactivity: | Human, Mouse |
| Clonality: | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.3), 0.5% BSA, 50% Glycerol, 0.02% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immoungen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | KAT2A antibody; GCN5 antibody; GCN5L2 antibody; HGCN5 antibody; Histone acetyltransferase KAT2A antibody; General control of amino acid synthesis protein 5-like 2 antibody; Histone acetyltransferase GCN5 antibody; HsGCN5 antibody; Lysine acetyltransferase 2A antibody; STAF97 antibody |
Target information
Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711).
Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on ‘Lys-79’ (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711).
Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711).
Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711).
In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711).
Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755).
Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711).
Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837).
Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity).
Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at ‘Lys-9’ (H3K9ac), leading to promote IL2 expression (By similarity).
Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at ‘Lys-9’ (H3K9ac) (By similarity).
Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity).
Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768).
Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768).
Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on ‘Lys-91’ (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).
Provider
Erpantech Laboratory
