Anti-JIP1/MAPK8IP1 antibody
Specifications
| Product Cat#: | AB-06-2533 |
| Product type: | Primary antibody |
| Antigen: | JIP1/MAPK8IP1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1 425-524/711 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | C jun amino terminal kinase interacting protein 1 |
| IB 1 | |
| IB1 | |
| Islet brain 1 | |
| JIP 1 | |
| JNK interacting protein 1 | |
| JNK MAP kinase scaffold protein 1 | |
| MAPK8IP 1 | |
| MAPK8IP1 | |
| Mitogen activated protein kinase 8 interacting protein 1 | |
| PRKM8 interacting protein | |
| PRKM8IP |
Target information
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8+ T-cells.
Provider
Erpantech Laboratory
