Anti-JAB1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | JAB1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:100-1:200); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JB34-96) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | 38 kDa Mov34 homolog antibody |
| COP9 (constitutive photomorphogenic) homolog subunit 5 antibody | |
| COP9 constitutive photomorphogenic homolog subunit 5 antibody | |
| COP9 signalosome complex subunit 5 antibody | |
| COP9 signalosome subunit 5 antibody | |
| Cop9 subunit 5 antibody | |
| COPS 5 antibody | |
| cops5 antibody | |
| CSN 5 antibody | |
| CSN5 antibody | |
| CSN5_HUMAN antibody | |
| JAB 1 antibody | |
| Jun activation domain binding protein 1 antibody | |
| Jun activation domain binding protein antibody | |
| Jun activation domain-binding protein 1 antibody | |
| MGC3149 antibody | |
| MOV 34 antibody | |
| MOV34 antibody | |
| MOV34 family, 38-KD member antibody | |
| SGN 5 antibody | |
| SGN5 antibody | |
| Signalosome subunit 5 antibody |
Target information
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Provider
Erpantech Laboratory
