Anti-Islet 1 Antibody
Specifications
| Product Cat#: | AB-06-2514 |
| Product type: | Primary antibody |
| Antigen: | Islet 1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunocytochemistry (1:80-1:200); Immunofluorescence; Immunoprecipitation |
| Reactivity: | Mouse and Human |
| Clonality (clone number): | Monoclonal(SC05-64) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Insulin gene enhancer protein ISL 1 antibody |
| Insulin gene enhancer protein ISL-1 antibody | |
| Insulin related protein antibody | |
| ISL 1 antibody | |
| ISL LIM homeobox 1 antibody | |
| ISL1 antibody | |
| ISL1 transcription factor LIM homeodomain antibody | |
| ISL1 transcription factor, LIM/homeodomain (islet 1) antibody | |
| ISL1 transcription factor, LIM/homeodomain antibody | |
| ISL1_HUMAN antibody | |
| Islet-1 antibody | |
| Islet1 antibody |
Target information
DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5′-ATAATTAA-3′ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
Provider
Erpantech Laboratory
