Anti-IRE1 antibody
Specifications
| Product Cat#: | AB-08-0110 |
| Product type: | Primary antibody |
| Antigen: | IRE1 |
| Immunogen: | Recombinant protein of human IRE1. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Immunofluorescence (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3. |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | ERN1; Endoplasmic Reticulum To Nucleus Signaling 1; Serine/Threonine-Protein Kinase/Endoribonuclease IRE1; IRE1P; Inositol-Requiring Protein 1; Inositol-Requiring Enzyme 1; ER To Nucleus Signalling 1; Ire1-Alpha; HIRE1p; IRE1a; Endoplasmic Reticulum-To-Nucleus Signaling 1; Protein Kinase/Endoribonuclease; Inositol-Requiring 1; EC 2.7.11 |
Target information
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Provider
Erpantech Laboratory
