Anti-Integrin Alpha 5 Antibody
Specifications
| Product Cat#: | AB-06-2469 |
| Product type: | Primary antibody |
| Antigen: | Integrin alpha 5 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunocytochemistry (1:80-1:200); Immunofluorescence; Immunohistochemistry (1:80-1:200); Immunoprecipitation; Flow Cytometry (1:80-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal(JJ08-94) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD49 antigen-like family member E antibody |
| CD49e antibody | |
| Fibronectin receptor subunit alpha antibody | |
| Fibronectin receptor, alpha subunit antibody | |
| FNRA antibody | |
| Integrin alpha 5 (fibronectin receptor alpha) antibody | |
| Integrin alpha-5 antibody | |
| Integrin alpha-5 light chain antibody | |
| Integrin alpha-F antibody | |
| Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) antibody | |
| ITA5_HUMAN antibody | |
| Itga5 antibody | |
| Very late activation protein 5, alpha subunit antibody | |
| VLA-5 antibody | |
| VLA5 antibody | |
| VLA5A antibody |
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Target information
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
Provider
Erpantech Laboratory