Anti-IL33 antibody
Specifications
| Product Cat#: | AB-06-2418 |
| Product type: | Primary antibody |
| Antigen: | IL33 |
| Immunogen: | KLH conjugated synthetic peptide derived from human IL-33 Propeptide 1-111/270 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry-Paraffin (1:500-800) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | IL-33 |
| Interleukin-33/Nuclear factor from high endothelial venules | |
| IL33 | |
| C9orf26 | |
| CHROMOSOME 9 OPEN READING FRAME 26 | |
| DKFZp586H0523 | |
| DVS27 | |
| DVS27 related protein | |
| IL 1F11 | |
| IL 33 | |
| IL1F11 | |
| Interleukin 1 family member 11 | |
| Interleukin 33 | |
| INTERLEUKIN 33 NFHEV | |
| Interleukin 33 precursor | |
| Interleukin33 | |
| NF HEV | |
| NFEHEV | |
| NFHEV | |
| Nuclear factor from high endothelial venules | |
| RP11 575C20.2 IL33_HUMAN. |
Target information
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
Provider
Erpantech Laboratory