Anti-IL-18 Rabbit Polyclonal antibody
Specifications
| Product Cat#: | AB-08-0136 |
| Product type: | Primary antibody |
| Antigen: | IL-18 |
| Immunogen: | Synthetic peptide within mouse IL-18 aa 36-192. |
| Predicted molecular weight: | 22 kDa |
| Observed molecular weight: | 22/18 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:60-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 50% Glycerol, 0.05% NaN3. |
| Concentration: | - |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | IGIF; IL-18; IL-1g; IL1F4 |
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Target information
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850).
Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532).
Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
Provider
Erpantech Laboratory
