Anti-IL-1 beta Mouse Monoclonal antibody
Specifications
| Product Cat#: | AB-06-4994 |
| Product type: | Primary antibody |
| Antigen: | IL-1 beta |
| Immunogen: | Recombinant protein within Human IL-1 beta aa 117-269/269. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); ELISA (1:10000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A7A10 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 0.1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/mL |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Catabolin antibody |
| H1 antibody | |
| IFN beta inducing factor antibody | |
| IL 1 antibody | |
| IL 1 beta antibody | |
| IL-1 beta antibody | |
| IL1 antibody | |
| IL1 BETA antibody | |
| IL1B antibody | |
| IL1B_HUMAN antibody | |
| IL1F2 antibody | |
| Interleukin 1 beta antibody | |
| Interleukin 1 beta precursor antibody | |
| interleukin 1, beta antibody | |
| Interleukin-1 beta antibody | |
| OAF antibody | |
| Osteoclast activating factor antibody | |
| OTTHUMP00000162031 antibody | |
| Preinterleukin 1 beta antibody | |
| Preinterleukin beta antibody | |
| Pro interleukin 1 beta antibody | |
| IL-1beta |
Target information
Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819, PubMed:28331908).
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526).
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).
Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed:28331908).
Provider
Erpantech Laboratory
