Anti-IKK Beta antibody
Specifications
| Product Cat#: | AB-06-2382 |
| Product type: | Primary antibody |
| Antigen: | IKK beta |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunocytochemistry (1:80-1:200); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:80-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | I kappa B kinase 2 antibody |
| I kappa B kinase beta antibody | |
| I-kappa-B kinase 2 antibody | |
| I-kappa-B-kinase beta antibody | |
| IkBKB antibody | |
| IKK beta antibody | |
| IKK-B antibody | |
| IKK-beta antibody | |
| IKK2 antibody | |
| IKKB antibody | |
| IKKB_HUMAN antibody | |
| IMD15 antibody | |
| Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta antibody | |
| Inhibitor of nuclear factor kappa-B kinase subunit beta antibody | |
| NFKBIKB antibody |
Target information
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Provider
Erpantech Laboratory
