Anti-Ikk Alpha antibody
Specifications
| Product Cat#: | AB-06-2380 |
| Product type: | Primary antibody |
| Antigen: | Ikk alpha |
| Immunogen: | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to the N-terminal of IKK alpha. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:100-1:500); Immunocytochemistry (1:80-1:200); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:100-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | chuk antibody |
| CHUK1 antibody | |
| Conserved Helix Loop Helix Ubiquitous Kinase antibody | |
| Conserved helix loop ubiquitous kinase antibody | |
| Conserved helix-loop-helix ubiquitous kinase antibody | |
| I Kappa B Kinase 1 antibody | |
| I Kappa B Kinase Alpha antibody | |
| I-kappa-B kinase 1 antibody | |
| I-kappa-B kinase alpha antibody | |
| IkappaB kinase antibody | |
| IkB kinase alpha subunit antibody | |
| IkBKA antibody | |
| IKK 1 antibody | |
| IKK A antibody | |
| IKK a kinase antibody | |
| IKK-A antibody | |
| IKK-alpha antibody | |
| IKK1 antibody | |
| IKKA antibody | |
| IKKA_HUMAN antibody | |
| Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody | |
| Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody | |
| Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody | |
| NFKBIKA antibody | |
| Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody | |
| Nuclear factor NF kappa B inhibitor kinase alpha antibody | |
| Nuclear factor NF-kappa-B inhibitor kinase alpha antibody | |
| Nuclear factor NFkappaB inhibitor kinase alpha antibody | |
| Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody | |
| TCF-16 antibody | |
| TCF16 antibod |
Target information
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at ‘Ser-10’ that are subsequently acetylated at ‘Lys-14’ by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
Provider
Erpantech Laboratory
