Anti-IKK-γ antibody
Specifications
| Product Cat#: | AB-07-0669 |
| Immunogen: | A synthetic peptide derived from human IKK-γ. The exact amino-acid sequence is proprietary. |
| Antigen: | IKK-γ |
| Product type: | Primary antibody |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500~1:3000); ELISA (1:40000) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | FIP-3, FIP3, I-kappa-B kinase gamma, IKBKG, IKK-gamma, IKKAP1, IKKG, IkB kinase gamma subunit, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase gamma subunit, NEMO, NF-kappaB essential modifier, NF-kappaB essential modulator, mFIP-3 |
Target information
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ‘Lys-63’-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires ‘Lys-27’-linked polyubiquitination.
Provider
Erpantech Laboratory
