Anti-IGF I antibody
Specifications
| Product Cat#: | AB-06-2357 |
| Product type: | Primary antibody |
| Antigen: | IGF I |
| Immunogen: | KLH conjugated synthetic peptide derived from human IGF I 108-195/195 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1800); Immunohistochemistry-Paraffin (1:500-800) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep |
| Clonality (clone number): | polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein Aaffinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | IBP1 |
| IGF 1 | |
| IGF I | |
| IGF-1 | |
| IGF IA | |
| IGF IB | |
| IGF1 | |
| IGFI | |
| IGFIA | |
| Insulin like growth factor 1 (somatomedin C) | |
| Full=insulin-like growth factor I | |
| Insulin like growth factor 1 | |
| Insulin like growth factor IA | |
| Insulin like growth factor IB | |
| Mechano growth factor | |
| MGF | |
| Mechano growth factor | |
| MGF | |
| Somatomedia C | |
| Somatomedin C |
Target information
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).
Provider
Erpantech Laboratory
