Anti-IFN Alpha R1 antibody
Specifications
| Product Cat#: | AB-06-2343 |
| Product type: | Primary antibody |
| Antigen: | IFN alpha R1 |
| Immunogen: | The extracellular domain of IFN-αR1 of mouse origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1:1000); Immunoprecipitation: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate); Flow Cytometry (1:100-1:200) |
| Reactivity: | Mouse |
| Clonality (clone number): | Monoclonal (2G1) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Alpha type antiviral protein antibody |
| Antiviral protein, alpha-type antibody | |
| Antiviral protein, beta-type antibody | |
| AVP antibody | |
| Beta type antiviral protein antibody |
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Target information
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).
Provider
Erpantech Laboratory