Anti-HuR ELAVL1 antibody
Specifications
| Product Cat#: | AB-06-2318 |
| Product type: | Primary antibody |
| Antigen: | HuR ELAVL |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunoprecipitation(1:10-1:60); Immunohistochemistry (1:100-1:600); Flow Cytometry (1:60-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody |
| ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) antibody | |
| ELAV like 1 antibody | |
| ELAV like RNA binding protein 1 antibody | |
| ELAV-like protein 1 antibody | |
| ELAV1 antibody | |
| ELAV1_HUMAN antibody | |
| Elavl1 antibody | |
| Embryonic lethal abnormal vision drosophila homolog like 1 antibody | |
| Hu Antigen R antibody | |
| Hu-antigen R antibody | |
| Hua antibody | |
| HuR antibody |
Target information
RNA-binding protein that binds to the 3′-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3′-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5′-UUUU[AG]UUU-3′ motif in vitro (PubMed:8626503). With ZNF385A, binds the 3′-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3′ UTR (PubMed:29180010).
Provider
Erpantech Laboratory
