Anti-HnRNP C1+C2 antibody
Specifications
| Product Cat#: | AB-06-2229 |
| Product type: | Primary antibody |
| Antigen: | HnRNP C1+C2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:5000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:80-1:500); Flow Cytometry (1:40-1:100); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Mouse, Rat, Human and Zebrafish |
| Clonality (clone number): | Monoclonal （SN0652） |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C1 antibody |
| C2 antibody | |
| Heterogeneous nuclear ribonucleoprotein C (C1/C2) antibody | |
| Heterogeneous nuclear ribonucleoprotein C antibody | |
| Heterogeneous nuclear ribonucleoproteins C1/C2 antibody | |
| HNRNP antibody | |
| HnRNP C1 / hnRNP C2 antibody | |
| HnRNP C1/C2 antibody | |
| Hnrnpc antibody | |
| HNRPC antibody | |
| HNRPC_HUMAN antibody | |
| MGC104306 antibody | |
| MGC105117 antibody | |
| MGC117353 antibody | |
| MGC131677 antibody | |
| Nuclear ribonucleoprotein particle C1 protein antibody | |
| Nuclear ribonucleoprotein particle C2 protein antibody | |
| SNRPC antibody |
Target information
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3′-UTR or 5′-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ‘m6A-switch’, facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Provider
Erpantech Laboratory