Anti-HLA Class 1 ABC Antibody [EMR8-5] (ab70328)
Specifications
| Product Cat#: | ab70328 |
| Product type: | Primary antibody |
| Antigen: | HLA Class 1 ABC |
| Immunogen: | Full length protein corresponding to HLA Class 1 ABC. Recombinant HLA-A*2402 extracellular domain. |
| Species immunized: | Mouse |
| Isotype: | IgG1, kappa |
| Applications: | Flow Cyt, IHC-P, WB |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, EMR8-5 |
| Form: | Liquid |
| Buffer: | pH: 7.40, Preservative: 0.05% Sodium azide, Constituent: PBS |
| Concentration: | 1 mg/mL |
| Purity: | Protein A purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Antigen Presenting Molecule antibody |
| Cw*1701 antibody | |
| D6S204 antibody | |
| FLJ27082 antibody | |
| HLA A antibody | |
| HLA B antibody | |
| HLA C antibody | |
| HLA class 1 A antibody | |
| HLA class 1 B antibody | |
| HLA class 1 C antibody | |
| HLA JY3 antibody | |
| HLAA antibody | |
| HLAB antibody | |
| HLAC antibody | |
| HLC C antibody | |
| Human Leucocyte Antigen C antibody | |
| Major Histocompatibility Complex Class I A antibody | |
| Major Histocompatibility Complex Class I B antibody | |
| Major Histocompatibility Complex Class I C antibody | |
| Major histocompatibility complex, class I, A + B + C antibody | |
| MHC class I antigen A*1 antibody | |
| MHC Class I Antigen antibody | |
| MHC class I antigen B*7 antibody | |
| MHC class I antigen Cw*1 antibody | |
| MHC class I HLA A antibody | |
| MHC class I HLA B antibody | |
| MHC class I HLA C antibody | |
| MHC HLA ABC antibody | |
| PSORS1 antibody |
Target information
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417).
May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507).
Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417).
Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119).
Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).
