Anti-Histone H3.3 antibody
Specifications
| Product Cat#: | AB-06-2197 |
| Product type: | Primary antibody |
| Antigen: | Histone H3.3 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200); Immunofluorescence; Chromatin Immunoprecipitation |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (ST50-08) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | H3 histone family 3A antibody |
| H3 histone family 3B antibody | |
| H3 histone, family 3B (H3.3B) antibody | |
| H3.3 antibody | |
| H3.3A antibody | |
| H3.3B antibody | |
| H33_HUMAN antibody | |
| H3F3 antibody | |
| H3F3A antibody | |
| H3f3b antibody | |
| Histone H3.3 antibody | |
| Histone H3.3Q antibody | |
| Histone H3.A antibody | |
| Histone H3.B antibody | |
| MGC87782 antibody | |
| MGC87783 antibody |
Target information
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Provider
Erpantech Laboratory