Anti-Histone H2A.X antibody
Specifications
| Product Cat#: | AB-06-2177 |
| Product type: | Primary antibody |
| Antigen: | Histone H2A.X |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunoprecipitation(1:10-1:60); Immunohistochemistry(1:100-1:200); Immunofluorescence(1:60-1:200); Immunocytochemistry; Western Blot (1:600-1:2000) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, JM06-42 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AW228881 antibody |
| H2A histone family member X antibody | |
| H2A.FX antibody | |
| H2A.X antibody | |
| H2a/x antibody |
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Target information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Provider
Erpantech Laboratory
