Anti-HEMK2 antibody
Specifications
| Product Cat#: | AB-06-2126 |
| Product type: | Primary antibody |
| Antigen: | HEMK2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human HEMK2 1-100/214 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000) |
| Reactivity: | Human, Mouse, Rat, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | affinity purified by Protein A |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C21orf127 |
| Chromosome 21 open reading frame 127 | |
| EC 2.1.1.- | |
| HemK methyltransferase family member 2 | |
| HemK2 | |
| M.HsaHemK2P | |
| MGC19995 | |
| MTQ2 | |
| N-6 adenine-specific DNA methyltransferase 1 | |
| N-6 adenine-specific DNA methyltransferase 1 (putative) | |
| N6-DNA-methyltransferase | |
| N6AMT | |
| N6AMT1 | |
| OTTHUMP00000096393 | |
| OTTHUMP00000096394 | |
| PRED28 |
Target information
Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on ‘Gln-185’; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N6-methyladenosine) (PubMed:30017583). N6-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).
Provider
Erpantech Laboratory
