Anti-HDAC2 antibody (KO Validated)
Specifications
| Product Cat#: | AB-06-2106 |
| Product type: | Primary antibody |
| Antigen: | HDAC2 |
| Immunogen: | Synthetic peptide within Human HDAC2 aa 439-488/488. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry/Immunofluorescence; (1:100-1:200); Immunohistochemistry-Paraffin (1:100-1:200); Flow Cytometry (1:50-1:200); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SY29-02) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | D10Wsu179e antibody |
| HD 2 antibody | |
| HD2 antibody | |
| HDAC 2 antibody | |
| Hdac2 antibody | |
| HDAC2_HUMAN antibody | |
| Histone deacetylase 2 (HD2) antibody | |
| Histone deacetylase 2 antibody | |
| OTTHUMP00000017046 antibody | |
| OTTHUMP00000227077 antibody | |
| OTTHUMP00000227078 antibody | |
| RPD3 antibody | |
| transcriptional regulator homolog RPD3 antibody | |
| YAF1 antibody | |
| YY1 associated factor 1 antibody | |
| YY1 transcription factor binding protein antibody | |
| Yy1bp antibody |
Target information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Provider
Erpantech Laboratory