Anti-GRIA2 antibody
Specifications
| Product Cat#: | AB-06-2037 |
| Product type: | Primary antibody |
| Antigen: | GRIA2 |
| Immunogen: | Purified recombinant fragment of human Glutamate receptor 2 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG2b |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (A3-A7) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AMPA 2 antibody |
| AMPA selective glutamate receptor 2 antibody | |
| AMPA-selective glutamate receptor 2 antibody | |
| AMPA2 antibody | |
| GluA2 antibody | |
| GLUR 2 antibody | |
| GLUR B antibody | |
| GluR K2 antibody | |
| GluR-2 antibody | |
| GluR-B antibody | |
| GluR-K2 antibody | |
| GLUR2 antibody | |
| GLURB antibody | |
| Glutamate receptor 2 antibody | |
| Glutamate receptor ionotropic AMPA 2 antibody | |
| Glutamate receptor ionotropic antibody | |
| Gria2 antibody | |
| GRIA2_HUMAN antibody | |
| HBGR2 antibody |
Target information
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Provider
Erpantech Laboratory
