Anti-GRB2 (Phospho-Ser159) antibody
Specifications
| Product Cat#: | AB-07-2941 |
| Product type: | Primary antibody |
| Antigen: | GRB2 (Phospho-Ser159) |
| Immunogen: | A synthetic peptide derived from human GRB2. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:3000); ELISA (1:40000) |
| Reactivity: | Mouse, Human, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GABJ; GRB2-associated binding protein 2; KIAA0571; pp100 |
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Target information
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Provider
Erpantech Laboratory
