Anti-Granzyme B antibody
Specifications
| Product Cat#: | AB-07-2939 |
| Product type: | Primary antibody |
| Antigen: | Granzyme B |
| Immunogen: | A synthetic peptide derived from human Granzyme B. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:3000); ELISA (1:5000); Immunohistochemistry (1:50-1:100) |
| Reactivity: | Mouse, Human, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 3.4.21.79, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, PROTEASE SERINE B, T-cell serine protease 1-3E, cathepsin G-like 1, cytotoxic serine protease B, fragmentin 2, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1 |
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Target information
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Provider
Erpantech Laboratory
