Anti-GPR52 antibody
Specifications
| Product Cat#: | AB-06-2011 |
| Product type: | Primary antibody |
| Antigen: | GPR52 |
| Immunogen: | KLH conjugated synthetic peptide derived from human GPR52 151-250/361 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | GPCR GPR52 |
| axor10 | |
| G protein coupled receptor 52 | |
| GPR52 | |
| GPR52_HUMAN | |
| Probable G protein coupled receptor 52 | |
| Probable G-protein coupled receptor 52 |
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Target information
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).
Provider
Erpantech Laboratory
