Anti-Glutamine Synthetase antibody
Specifications
| Product Cat#: | AB-06-1947 |
| Product type: | Primary antibody |
| Antigen: | Glutamine synthetase |
| Immunogen: | KLH conjugated synthetic peptide derived from human Glutamine synthetase 285-373/373 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunohistochemistry-Paraffin (1:400-1:800); Flow Cytometry (1ug/Test) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | cell proliferation-inducing protein 59 |
| GLNA | |
| GLNA_HUMAN | |
| GLNS | |
| GLUL | |
| Glutamate ammonia ligase | |
| Glutamate decarboxylase | |
| Glutamate–ammonia ligase | |
| glutamine synthase | |
| Glutamine synthetase | |
| GS | |
| PIG 43 | |
| PIG 59 | |
| PIG43 | |
| PIG59 |
Target information
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351).
Provider
Erpantech Laboratory
