Anti-Glucocorticoid Receptor Alpha antibody
Specifications
| Product Cat#: | AB-06-1929 |
| Product type: | Primary antibody |
| Antigen: | Glucocorticoid Receptor Alpha |
| Immunogen: | Recombinant full length protein corresponding to Human Glucocorticoid Receptor alpha. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000-1:5000); Flow Cytometry (1:50-1:100); Immunohistochemistry (1:50-1:200); |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (3F2) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2 mg/ml |
| Purity: | Protein G affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | GCCR antibody |
| GCR antibody | |
| Glucocorticoid receptor alpha isoform antibody | |
| Glucocorticoid receptor antibody | |
| GR antibody | |
| GRL antibody | |
| NR3C1 antibody | |
| Nuclear receptor subfamily 3 group C member 1 antibody |
Target information
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5′ UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
Provider
Erpantech Laboratory
