Anti-Gli3 antibody
Specifications
| Product Cat#: | AB-06-1915 |
| Product type: | Primary antibody |
| Antigen: | Gli3 |
| Immunogen: | Recombinant protein within human Gli3 aa 1300-1600 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JG83-39) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | ACLS antibody |
| DNA binding protein antibody | |
| GCPS antibody | |
| Gli 3 antibody | |
| GLI family zinc finger 3 antibody | |
| GLI Kruppel family member GLI 3 antibody | |
| GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) antibody | |
| GLI Kruppel family member GLI3 antibody | |
| GLI3 antibody | |
| GLI3 C-terminally truncated form antibody | |
| GLI3 form of 190 kDa antibody | |
| GLI3 form of 83 kDa antibody | |
| GLI3 full length protein antibody | |
| GLI3-190 antibody | |
| GLI3-83 antibody | |
| GLI3_HUMAN antibody | |
| GLI3FL antibody | |
| Glioma associated oncogene family zinc finger 3 antibody | |
| Oncogene GLI3 antibody | |
| PAP A antibody | |
| PAPA 1 antibody | |
| PAPA antibody | |
| PAPA1 antibody | |
| PAPB antibody | |
| PHS antibody | |
| PPD IV antibody | |
| PPDIV antibody | |
| Transcriptional activator GLI3 antibody | |
| Transcriptional repressor GLI3R antibody | |
| Zinc finger protein GLI 3 antibody |
Target information
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5′-GGGTGGTC-3′.
Provider
Erpantech Laboratory
