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Anti-GCLM antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1869
Anti-GCLM antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1869
Product type: Primary antibody
Antigen: GCLM
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:100); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:50-1:200); Immunofluorescence; Immunoprecipitation
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal, JM93-61
Form: Liquid
Buffer: 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Alternative names: Gamma ECS regulatory subunit antibody
Gamma-ECS regulatory subunit antibody
Gamma-glutamylcysteine synthetase regulatory subunit antibody
GCLM antibody
GCS light chain antibody
GLCLR antibody
Glutamate cysteine ligase regulatory subunit antibody
Glutamatecysteine ligase modifier subunit antibody
Glutamatecysteine ligase regulatory subunit antibody
GSC light chain antibody
GSH0_HUMAN antibody
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Target information

Gamma-glutamylcysteine synthetase (γ-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. γ-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human gamma-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human γ-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of γ-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

Provider

Erpantech Laboratory

download

MSDS-AB-06-1869.pdf (156 downloads )