Anti-GATA4 antibody
Specifications
| Product Cat#: | AB-06-1860 |
| Product type: | Primary antibody |
| Antigen: | GATA4 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (7-4) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | ASD2 antibody |
| GATA 4 antibody | |
| GATA binding protein 4 antibody | |
| GATA-binding factor 4 antibody | |
| gata4 antibody | |
| GATA4_HUMAN antibody | |
| MGC126629 antibody | |
| Transcription factor GATA 4 antibody | |
| Transcription factor GATA-4 antibody | |
| Transcription factor GATA4 antibody | |
| VSD1 antibody |
Target information
Transcriptional activator that binds to the consensus sequence 5′-AGATAG-3′ and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
Provider
Erpantech Laboratory
