Anti-GABRB2 antibody
Specifications
| Product Cat#: | AB-06-1820 |
| Product type: | Primary antibody |
| Antigen: | GABRB2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human GABRB2/GABA A Receptor beta 2 251-350/512 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | GABA A Receptor beta 2 |
| GABA | |
| GABA(A) receptor subunit beta-2 | |
| GABRB2 | |
| Gamma aminobutyric acid (GABA) A receptor, beta 2 | |
| Gamma aminobutyric acid A receptor beta 2 | |
| Gamma-aminobutyric acid receptor subunit beta-2 | |
| Gamma-aminobutyric-acid receptor subunit beta-2 |
Target information
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
Provider
Erpantech Laboratory
