Anti-G3BP Recombinant Rabbit Monoclonal antibody
Specifications
| Product Cat#: | AB-17-2025 |
| Product type: | Primary antibody |
| Antigen: | G3BP |
| Immunogen: | A synthetic peptide of human G3BP. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunocytochemistry/Immunofluorescence (1:50-1:200); Immunoprecipitation (1:20); Immunohistochemistry (1:50-1:100) |
| Reactivity: | Human, Rat, Mouse |
| Clonality (clone number): | Monoclonal, R06-5D2 |
| Form: | Liquid |
| Buffer: | Tris-Glycine buffer (pH 7.4), 0.05% BSA, 40% glycerol, 0.01% NaN3. |
| Concentration: | 0.3 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1 |
Target information
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity (PubMed:30510222).
Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA (PubMed:30804210).
In addition, plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204).
Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3′ tail or hanging tails at both 5′- and 3′-ends (PubMed:9889278).
Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278).
Acts unidirectionally by moving in the 5′ to 3′ direction along the bound single-stranded DNA (PubMed:9889278).
Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510).
Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3′-UTR (PubMed:11604510).
Provider
Erpantech Laboratory
