Anti-G21 Protein/NPR2L antibody
Specifications
| Product Cat#: | AB-06-1807 |
| Product type: | Primary antibody |
| Antigen: | G21 Protein/NPR2L |
| Immunogen: | KLH conjugated synthetic peptide derived from human NPR2L 221-320/380 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | G21 protein |
| Gene 21 protein | |
| Homologous to yeast nitrogen permease (candidate tumor suppressor) | |
| Homologous to yeast nitrogen permease | |
| NPR 2L | |
| NPR L2 | |
| NPR like 2 | |
| NPR2 like | |
| NPRL 2 | |
| NPRL2 | |
| Tumor suppressor candidate 4 | |
| TUSC 4 | |
| TUSC 4 protein | |
| TUSC4 | |
| TUSC4 protein |
Target information
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at ‘Tyr-9’, ‘Tyr-373’ and ‘Tyr-376’ residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
Provider
Erpantech Laboratory
