Anti-FZR1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | FZR1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human FZR1/CDC20C 141-240/496 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin(1:400-1:850) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CDC20 like 1b |
| CDC20 like protein 1 | |
| CDC20-like protein 1 | |
| CDC20C | |
| Cdh 1 | |
| CDH1 | |
| Cdh1/Hct1 homolog | |
| Fizzy related protein 1 | |
| Fizzy related protein 1 | |
| Fizzy related protein | |
| Fizzy related protein homolog | |
| Fizzy-related protein homolog | |
| Fizzy/cell division cycle 20 related 1 | |
| FYR | |
| FZR 1 | |
| FZR 2 | |
| FZR | |
| FZR_HUMAN | |
| FZR1 | |
| Fzr1 protein | |
| FZR2 | |
| HCDH 1 | |
| HCDH | |
| HCDH1 |
Target information
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) .
Provider
Erpantech Laboratory
