Anti-Fusion glycoprotein F0 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | DKK1 |
| Immunogen: | Synthetic peptide corresponding to Avian avulavirus 1 Fusion glycoprotein F0 aa 540-554. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); ELISA(1:4500-1:10000) |
| Reactivity: | Avian avulavirus 1 |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Peptide affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Fusion glycoprotein F0 antibody |
| Fusion glycoprotein F1 antibody | |
| Fusion glycoprotein F2 antibody | |
| Fusion protein (F) antibody | |
| RSV fusion protein antibody |
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Target information
During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
Provider
Erpantech Laboratory
